AutoGen is the heavy hitter for developers who want agents that actually *do* things, not just talk. Its standout feature is the ability to execute code safely in Docker containers, making it the go-to choice for building coding assistants or data analysis bots. However, the conversation-driven paradigm can be chaotic to debug compared to graph-based flows. Use this if you need powerful, autonomous code execution; avoid it if you just need a simple, linear chain of LLM calls.